ABSTRACT
Es conocido que la radiación ha sido asociada a una cicatrización disminuida de las heridas, necrosis grasa y decoloración. La quimioterapia, por otra parte, se ha descrito con efectos adversos como infección, necrosis, contractura o deformación de los colgajos. Los antecedentes previos son los causantes de cierta confusión al enfrentar pacientes oncológicos que durante su evolución requieren solucionar defectos de piel y tejidos blandos: es seguro realizar injertos o colgajos en un paciente que está siendo tratado con quimio o radioterapia? Por medio de la revisión de la literatura publicada buscamos dar respuesta a esta interrogante.
It is known that the radiation has been associated with decreased wound healing, fat necrosis and bleaching. Chemotherapy, on the other hand, has been described with side effects as infection, necrosis, contraction or deformation of the flaps. The previous history are causing some confusion that may arise when facing cancer patients that during their evolution require fix skin and soft tissue defects: is it safe do grafts or flaps in a patient being treated with chemotherapy or radiation therapy? Through the review of the published literature we seek to answer this question.
Subject(s)
Humans , Male , Female , Child , Adult , Skin Abnormalities/drug therapy , Surgical Flaps , Neoplasms/surgery , Chemotherapy, Adjuvant/adverse effects , Radiotherapy, Adjuvant/adverse effects , Transplants/abnormalities , Skin Abnormalities/radiotherapy , Neoplasms/drug therapy , Neoplasms/radiotherapy , Skin , Combined Modality Therapy/adverse effectsABSTRACT
Introduction: Vitiligo patients resistant to medical therapy pose a therapeutic problem to physicians. There are various surgical procedures for correcting stable vitiligo
Aim of work: To evaluate the efficacy of small [2-mm] punches minigraft therapy in relation to the patient age, disease site, subtype and the duration of stability of vitiligo
Patients and Methods: We used disposable 2.0-mm punch apparatus to perform minigraft therapy in 50 patients with different age range groups. Patients had either geheralized, segmental or local vitiligo, at variable sites. The duration of stability of vitiligo was different among studied patients
Results: Grading of repigmentation was assessed in relation to the age range with better results obtained in younger population [<20 years]. As regards the site of lesion, the face showed the statistically significant higher percentage of excellent response [88.89%] [P<0.05]. Segmental type of vitiligo was found to yield the best results. A significant positive correlation was detected between repigmentation score and the duration of stability of vitiligo [r=0.234, P<0. 05]
Conclusion: Age <20 years old, site of vitiligo patches, segmental subtype and longer duration of stability have positive influence on results of minigraft in patients with long standing vitiligo